As people settled in St. Bernard, the land along Bayou Terre-aux-Boeufs and the other bayous was favored as it was rich with clay, silt, sand, and gravel deposits caused by flooding over the years. It was also convenient to the Mississippi River, which facilitated the transportation of crops.

During the late 1700s New Orleans born Louis de Reggio assembled a plantation where Bayou Terre-aux-Boeufs and Bayou La Loutre come together by purchasing lands from the IsleƱos immigrants. Reggio and his brother-in-law, Nicolas Olivier de Vezin, also put together a large sugar plantation on the western edge of the Reggio Plantation.

Louis Reggio died in 1850 and his son, Auguste de Reggio continued in possession of the plantation. The Reggio family created a sugar empire that was so large it extended into other parishes and even included a railroad stop at the Reggio Plantation, which during the 19th and early 20th centuries picked up sugar on its way to New Orleans for shipment from the port.